Penny feels guilty after she and Nico take money to play with Ralphie, a lonely American boy.

Grandpa Pruitt's Iowa "horse-trading" talents come in handy when his family faces eviction because their Roman apartment building is about to be torn down.

The Endicotts take an American girl, an exotic dancer down on her luck in Rome, and try to give her a new lease on life.

The countess has a problem: her son is in love with the professor's daughter. Both are poor and this marriage would be a financial failure. Love can overcome all and they decide they will wait.

Penny is attracted to a slightly older boy Roy while Grandpa wants to date Stephanie, a lady young enough to be his daughter.

The Roman neighborhood of Trastevere is looking for the girl to represent them in a beauty contest. The organizers decide that the professor is the judge, but the drawback is that the proposed beauty is his own daughter.

Prof. Mike Endicott and his new neighbor, a Japanese instructor in Oriental flower arrangement, face the same problem—teen-age daughters who want more freedom — in the episode presented on "To Rome With Love;" when the series moves to a new day and time Wednesday, Jan. 13 (8:30-9) on the CBS Television Network. It's like a United Nations under one Italian roof when the Oriental and occidental cultures collide . Mike's daughter, Alison, wants her own apartment and Mr. Okada's daughter, Etsu, who feels as restricted as her father's 175-year-old bonsai plant, wants to adopt Alison's Western ways. Each father is concerned about his daughter's influence on the other. John Forsythe and Walter Brennan star in the series as Prof. Mike Endicott and Grandpa Andy Pruitt, respectively, with Joyce Menges, Susan Neher and Melanie Fullerton as Mike's daughters, Alison, Penny and Pokey. Peggy Mondo appears in a recurring role as Mama Vitale. Teru Shimada heads the guest cast as Mr. Okada, with Beulah Quo as his wife and Miko Mayama as their daughter Etsu. Forsythe's own daughter, Page, appears in a supporting role as Sandy Allen.

While making her film debut in an underground film Alison decides the hippie lifestyle looks appealing. She informs her dad Mike she wants to wander Europe as a vagabond.

Signora Vitale's very pregnant niece Christina is visiting and unexpectedly goes into labor. The Endicott household is thrown into an uproar, a doctor is unavailable and Grandpa Pruitt's dubious delivery skills are called upon.

Poignant good-byes are in the offing as the Endicotts tend two birds about to leave the nest: and injured dove – and Allison, who's being groomed for an art scholarship in Paris.

Penney and Pokey secretly leave home as they feel they are preventing Michael's marriage to a fashionable stewardess. A frantic search for the missing girls ensues.

Grandpa Pruitt is smitten with Mrs. Kinneman, an attractive widow from Illinois, while Alison falls for Jerry, a boy next door type from Iowa.

Grandpa plays a key role in a battle between the Endicotts' fellow tenants and their anonymous landlord.

Paolo, a mute boy who lives abandoned in the streets, is taken by Penny to the house of the Endicotts. After bathing him, dressing him and feeding him, the boy continues to be sullen and surly.

A crossover episode with the cast of "Family Affair". Mr. French, Cissy, Buffy, and Jody's trip to Nairobi is interrupted when Interpol officers at Rome Airport, mistaking Mr. French for a jewel thief, detain them. Mike Endicott (John Forsythe) intervenes, only to be implicated as Mr. French's accomplice.

A movie star invites the Endicotts to a premiere and set visit, prompting seven-year-old Pokey's rebellion against being treated like a child.

Grandpa Andy Pruitt joins the family in Rome, and is left to care for the girls while Endicott enjoys himself in Venice. But how can they tell him that he's a real drag on their social and business ventures?