Lincoln must say goodbye to yet another loved one as he attempts to reunite with Michael; Michael's attempt to secure a getaway plane is grounded; Mahone deciphers a crucial puzzle piece; T-Bag gets his revenge on his tormentors; and Sara and Kellerman have a tense face-off that leaves one of them gasping for their last breath.

T-Bag goes postal to track down a missing Mrs. Hollander. Sucre's escape plane faces deadly turbulence. Bellick has the tables turned on him upon his return to Fox River Penitentiary. Michael and Lincoln are taken into custody to be transported back to Fox River, forcing Mahone and Kellerman to take drastic measures to ensure that the brothers make it to the prison morgue instead of their cells. And a surprising ally changes the game for everyone.