In the next action-packed chapter of PRISON BREAK, original series stars Wentworth Miller, Dominic Purcell, Sarah Wayne Callies, Amaury Nolasco, Robert Knepper, Rockmond Dunbar and Paul Adelstein are reunited for an all-new adventure spanning the globe. When clues surface that suggest a previously thought-to-be-dead MICHAEL SCOFIELD (Miller, "The Loft") may be alive, his brother, LINCOLN BURROWS (Purcell, "DC's Legends of Tomorrow"), reunites with Michael's wife, SARA (Callies, "Colony," "The Walking Dead"), and Fox River State Penitentiary's most notorious escapees to engineer the series' biggest breakout ever.

The major storyline for the fourth season is about a team recruited by Homeland Security agent Don Self to obtain the Scylla. Although the team initially believes it to be The Company's "black book," it is later revealed to contain information on an advanced renewable power cell. 

Just when they thought they were out, they are pulled back in for the most dangerous escape ever.