Sara weighs sacrificing herself in order for Michael and Lincoln to set sail to freedom; T-Bag's reign of terror continues south of the border as Bellick forces Sucre to track down the missing money; Mahone's actions finally catch up with him; and an escapee finally tastes freedom.

Michael races against the clock to rescue Lincoln and beat Mahone at his own end game; Sucre risks his life to save a missing Maricruz; Kellerman's testimony at Sara's trial proves deadly; and T-Bag and Bellick find themselves up a Panamanian river.