T-Bag goes postal to track down a missing Mrs. Hollander. Sucre's escape plane faces deadly turbulence. Bellick has the tables turned on him upon his return to Fox River Penitentiary. Michael and Lincoln are taken into custody to be transported back to Fox River, forcing Mahone and Kellerman to take drastic measures to ensure that the brothers make it to the prison morgue instead of their cells. And a surprising ally changes the game for everyone.

Michael, Lincoln and Kellerman face several roadblocks as they attempt to capture a protected Terrance Steadman; tragedy strikes the Mahone family; Bellick turns sour when a fellow inmate turns sweet on him; C-Note faces life on the run as a single parent; and T-Bag forces the Hollander family to play house with him.