As doctors and as humans, the five friends each face a maze of life's questions and decisions as they figure out their next steps.

Ik Joon handles a sensitive request from the troubled wife of a patient. A sudden piece of news threatens Suk Hyung's peace. 

Put in a stressful situation, Jae Hak looks to Joon Wan for advice on the right thing to do. Ik Joon accidentally uncovers an extraordinary secret.

 An urgent call sends Song Hwa rushing to the hospital to tend to a young patient. Ik Joon receives a plea from a desperate father.

Distracted by a problem in his personal life, Do Jae Hak struggles to get through the day. Meanwhile Chu Min Ha finds herself drowning in work.

An unforeseen problem just before a surgery forces Jung Won to make a tough decision. Meanwhile, Joon Wan is put on edge in the operating room. 

Kim Joon Wan waits for a response from Lee Ik Soon, who says she needs some time. Jung Won breaks painful news to the family of his longtime patient. 

Jang Gyu Wool can't get one kind word out of Ahn Jung Won, who seems especially cold to her. A difficult professor joins the cardiothoracic department.

Yang Suk Hyung's aloofness frustrates someone on his team. Jang Yoon Bok and Jang Hong Do witness a surprising side of Song Hwa outside the hospital. 

The hospital's med students are inspired by the doctors, who each look after their patients in their own ways. Lee Ik Joon gets a welcome visitor. 

For the first time in 20 years, everyone's finally working under the same roof. A patient with a familiar name finds Chae Song Hwa. 

Five friends whose friendship goes back to their days in med school are brought back together when a phone call interrupts each of their busy lives.