Police struggle to identify the body of a woman found floating in the Indian River; with only a piece of nautical rope, a strip of duct tape and some plastic bags to go on, they use every forensic tool they have to catch her killer.

Homicide investigators are convinced an apparent murder-suicide was staged but the experienced CSI on the scene disagrees; only the instincts of the cops, coupled with an outside forensic expert's opinion, convince authorities who the real killer is.

When Lanell Barsock is found murdered, it seems obvious to all that her boyfriend did it; when the forensic evidence comes in, investigators are astonished to learn they've arrested the wrong person.

A suitcase filled with unidentified human remains unlocks a missing person's case that has gone unsolved for years; the forensic analysis of a nearly-destroyed cellphone found in the suitcase reveals a mysterious selfie.

In 2016, Jamie Haggard went missing. It takes police two years to gather evidence against the last person to see her alive, her half-brother David.

Todd Kendhammer claims his wife was killed in a freak car accident, but the forensic evidence doesn't back him up. When a new defence team is hired, they bring in their own forensic experts who contradict the state's case.