In the premiere of Stupid Pet Tricks, David Letterman passes Sarah Silverman the Stupid Pet Tricks torch and shares with her a very special Top Ten List. Also, Sarah meets the SPT staff and smooths out some unexpected intra-office issues. On stage, Sarah welcomes a former rodeo clown and his shockingly agile best friend, a goat who can walk on two legs, a party animal that really knows how to get down, and a dog that's up there with the smartest animals in the world. But only one will take home the title of Stupidest Pet Trick of the Week!

After learning that the show is overbudget, Sarah is forced to make some difficult layoffs, and Judd Apatow fights for his job; Sarah hangs out with a ninja warrior hamster, a super chill chameleon, a rabbit athlete, and a skateboarding dog.