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Megamind's confidence is tested when Machiavillain finally reveals himself.
Megamind refuses to teach Keiko how to be a hero, so she goes undercover in the Doom Syndicate.
Chum clones himself to accomplish everything he needs to do, but things get out of hand.
Roxanne's rekindled friendship with an old camp buddy makes Megamind jealous.
Megamind's body-switching tech causes him and Roxanne to swap bodies.
Chum accidentally sprays a roach with an experimental substance, causing it to become a genius.
Megamind's accident causes Mr. Donut to lose his memory, which might turn him into a supervillain.
Megamind tries to win over the citizens of Metro City but finds his popularity tested by a new hero.
Megamind's former villain team, The Doom Syndicate, has returned. Our newly crowned blue hero must now keep up evil appearances until he can assemble his friends (Roxanne, Ol' Chum, and Keiko) to stop his former evil teammates from launching Metro City to the moon.