Les disparues de la gare is based on a true crime story set in Perpignan, Southern France; between 1995 and 2001, a teenage girl disappeared, and three young women were murdered around the train station. They are young, beautiful and driven by a strong desire for emancipation. Their faces are displayed in the newspapers. They become "Les Disparues de la gare".

Flore Robin, a young investigator, took her first steps with the police on the same day that the first body was found. She will have to team up with police captain Franck Vidal and his mentor Felix Sabueso, who were long put in the closet but were given special attention to this out-of-the-box. At the same time, the mother of the missing girl explores each avenue to find her daughter. For 20 years, when a real psychosis gradually hits the city, the hunt for a ruthless serial killer is raging.