Michael learns that a patient at the clinic has a special connection to Anna. Meanwhile, Michael reunites with an old friend who is suffering from a rare illness.

When Michael's high school sweetheart comes to Holt Neuro with an irreversible condition, he will stop at nothing to try and save her, until Anna intervenes. Meanwhile, Zeke deals with the news that his best friend's cancer has returned.

When a spoiled pop star comes to Holt Neuro experiencing unusual symptoms, and a young girl at the Clinica exhibits similar symptoms on the same day, it forces both teams of doctors to try and piece together their common link.

Distraught woman takes the Clinica staff hostage after Michael testifies for a former patient who he believed suffered uncontrollable urges due to a brain tumor.

Michael saves a man from drowning and learns his identity is a mystery. Meanwhile, Kate discovers a girl she mentors has serious issues that she has failed to notice.

Michael and E-Mo disagree about how to treat a patient with a brain tumor. Meanwhile, a teenage girl gives birth at the clinic and immediately runs out, leaving the baby behind.

While tending to patients at the clinic during a blizzard, Michael shows signs of a severe condition that requires immediate surgery.

Michael and Kate are forced to work together to try and save a patient with a deadly virus. Meanwhile, at Holt Neuro, as Michael treats a nervous bride-to-be who is experiencing headaches, he notices her mother is exhibiting symptoms of a serious condition.

Rita's surprise Thanksgiving reunion with her son is interrupted when he has a motorcycle accident and it's up to Michael to save him. Meanwhile, Dr. Sykora and Dr. Barnes resuscitate a patient with a DNR.

When Michael finds out a patient with a malignant brain tumor committed a horrible crime, he struggles with whether to save the man's life. Meanwhile, a female firefighter who appears to be disoriented is brought to Holt Neuro for evaluation.

While at the clinic, Michael runs into a former football star that he performed successful surgery on years ago, and is now a shell of his former self, living on the streets. At Holt Neuro, Michael examines a patient who suffers from post-traumatic stress disorder.

Michael must decide if it is worth risking his practice to save a patient's life. Meanwhile, he courts Evan "E-Mo" Morris, a neuropsychiatrist to join his practice after E-Mo determines a patient's diagnosis by reading her body language.

When Michael treats a patient who is hearing voices, he turns to Anton for help. Meanwhile, Kate's first day at the clinic doesn't go well.

While interviewing doctors to run the clinic, Michael helps a man who passed out, but refuses care due to lack of insurance. Meanwhile, as Michael evaluates a woman, he notices lesions on her brain that require immediate surgery, even as he doesn't know the exact diagnosis.

Michael works double duty trying to save a pregnant personal friend he recently diagnosed with a brain tumor and a little boy with sickle cell disease.

After the ghost of Michael's ex-wife visits him from the afterlife and asks him to help continue running her low income clinic, he finds himself rushing back and forth between taking care of his own patients at Holt Neuro and her less fortunate patients at the clinic.