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Sacrifices are made when Echo leads her crew to Arizona to dismantle the Rossum Corporation's mainframe.
Topher races to reconstruct Echo's original personality and memories when Adelle realizes they are the key to adverting a devastating future. Meanwhile, Echo and Bennett's shared past and the identity of the Rossum's Corpration's mysterious leader are revealed.
Picking up from the events depicted in "Epitaph One," the "lost" episode of DOLLHOUSE, and set in the year 2020, Echo and her surviving Dollhouse crew attempt to restore order to a devastating future world before mankind is eliminated.
The Dollhouse is a very secret, and very illegal, place where wishes come true. Clients with the right connections and enough money can hire "Actives", people who have been programmed to perfectly fulfill the needs, and desires of their clients. The Actives are people who have chosen, for their own reasons, to surrender their bodies and minds for a five-year stay in the Dollhouse. Now they can be imprinted with any personality, skill, or even muscle memory. They can be the perfect companion, lover, spy, assassin; and when the job is done they forget everything. But something is wrong with the Active called "Echo". No longer just a blank slate waiting for her next assignment, Echo is remembering flashes of the lives that she has lived and the games she has played, and she is starting to wonder just who she really is.