Picking up from the events depicted in "Epitaph One," the "lost" episode of DOLLHOUSE, and set in the year 2020, Echo and her surviving Dollhouse crew attempt to restore order to a devastating future world before mankind is eliminated.

Sacrifices are made when Echo leads her crew to Arizona to dismantle the Rossum Corporation's mainframe.

Topher races to reconstruct Echo's original personality and memories when Adelle realizes they are the key to adverting a devastating future. Meanwhile, Echo and Bennett's shared past and the identity of the Rossum's Corpration's mysterious leader are revealed.

When Adelle, Boyd, and the rest of the Dollhouse fear that Echo's uncontrollable mind imprints are making her a danger to their goals, they send her to "the Attic" where Echo is forced to face her worst nightmare in order to survive.

As his contract with the Dollhouse expires, Victor is released back into the world, where his military past threatens his future with Sierra.

When Echo's past romantic engagements are found murdered, the Dollhouse fears that Alpha has returned to seek his revenge. Adelle grows suspicious of Ballard who hopes to find allies in Boyd and Topher. The Actives turn against their handlers, leaving one member of the house permanently mind-wiped.

In the aftermath of her entanglements at the D.C. Dollhouse, Echo finds herself out in the world struggling to keep her multiple personalities under control. Adelle finds her grip on the house challenged by Harding, and Boyd receives a mysterious phone call.

Echo is sent to stop Senator Daniel Perrin before he can expose the Dollhouse's secrets, and Adelle and Topher travel to the Washington, D.C. Dollhouse to meet its genius programmer, Bennett Halverson, a woman with a mysterious past connection to Echo.

Echo and Bennett have a shocking meeting as Adelle goes head-to-head with the ruthless head of the Washington, D.C. Dollhouse. Meanwhile, Topher sees double when he involves Victor in his espionage, and Perrin finds a surprising witness to testify against the Rossum Corporation.

Sierra is forced to face her past as her connection to the Rossum Corporation leads to obsession and murder.

Echo and Victor's imprints collide when Echo is sent on an assignment as a fun-loving, seductive college student and Victor is imprinted as the psychotic nephew of a Dollhouse shareholder.

When Echo is imprinted as a mother with a newborn baby, she takes too strongly to motherhood as a result of Topher's modifications. Meanwhile, Adelle pays November a visit, and Perrin ramps up his investigation into the Rossum Corporation.

Picking up a few months after the first season finale, Echo, who now sporadically remembers past "imprints" due to Alpha's machinations, weds a wealthy and charismatic British businessmen tied to one of Agent Ballard's open FBI cases. Dr. Saunders struggles with being an Active and makes Topher the target of her aggression, and Boyd mixes business with pleasure in a risky venture. Meanwhile, Adelle makes Ballard an offer he can't refuse.