To protect Guren from the raging Three Tails, Yuukimaru exerts powers beyond his limits. Moved by his action, Guren now comes to regret her past sin of killing Yuukimaru's mother.

The Leaf ninja learn that Naruto is inside the Three-Tailed beast. With no other alternative but to trust Yuukimaru's mystical senses, Kakashi and the others follow the boy's guidance and attempt a rescue mission...