The Uchiha clan was plotting a coup d'etat. The story as told by Madara leaves Sasuke at a loss for words. Because of his gifted talent, Itachi was forced to suffer, torn between his loyalties to the Leaf Village and the Uchiha clan.

In the Akatsuki hideout Sasuke comes face to face with Madara. Announcing himself as Itachi's accomplice from that fateful night, Madara goes on to tell Sasuke the truth about Itachi that he could never have known.

Naruto and his comrades find themselves held up by Tobi, whose strange jutsu is more than just a simple genjutsu.

At the climax of the battle, both Itachi and Sasuke run out of chakra. However, Sasuke reveals that his actions up until now were only a preparation for his final jutsu.

Sasuke loses his left eye to Itachi, but it turns out to be a genjutsu created by the Mangekyo Sharingan. Breaking free of the Tsukuyomi by force, Sasuke makes a furious comeback against the injured Itachi.

Following their fierce genjutsu battle with the Sharingan, Itachi explains the secret behind the most powerful ocular jutsu, the Mangekyo Sharingan, and the history of the Uchiha clan…

While Itachi waits for Sasuke in the Uchiha hideout, he recalls the past incident that led to his defection from the Leaf Village. When Sasuke arrives, the fated battle begins between the two brothers.

Sasuke arrives at one of the Akatsuki hideouts, having followed in Itachi's footsteps. When Sasuke is about to enter the hideout alone, his older brother Itachi finally appears before him…

Having lost his arm, Jiraiya is outmatched by the six Pains now appearing before him. Of the six, the one called Tendo is revealed to be Jiraiya's former student Yahiko. Jiraiya is still puzzled by the Rinnegan's true powers, but before he can gather his thoughts, he is forced back into battle.

Jiraiya completes his Sage Mode transformation to battle the three Pains.

Jiraiya battles to defeat his former student Pain, who is now driven by his twisted ideals as an Akatsuki member.

Foreseeing a possible battle, Jiraiya takes precautionary measures by releasing the scroll toad that commands the key to Naruto's Eight-Signed

Jiraiya successfully infiltrates the Hidden Rain Village by hiding inside the toad Gamagoro. He sets out to gather information but finds no indications of a civil war occurring within the village.

Jiraiya's journey to seek out a student is postponed due to the outbreak of the Third Great Ninja War. Jiraiya joins Tsunade and Orochimaru to battle the Village Hidden in the Rain. Following the battle, the three ninja are named the "Legendary Sannin," a title given to them by the enemy Hanzo of the Great Salamander himself.

During the reign of the Second Hokage, the young Jiraiya, Orochimaru, and Tsunade are assigned to Hiruzen Sarutobi's platoon as Genins. Fascinated by Sarutobi's summoning jutsu, Jiraiya immerses himself in mastering the transportation technique. While training, Jiraiya accidentally transports himself to Mount Myoboku, opening the path to fulfill his destiny.

Leaf ninja, she notifies the others and the Hebi members quickly leave the inn. To allow Sasuke to focus on his coming battle with Itachi, Karin comes up with a plan to keep the Leaf ninja occupied.

Sasuke goes missing after being caught by Deidara's suicidal bombing. Sensing his disappearance, Jugo, Karin, and Suigetsu race to Sasuke's last location, where the three Hebi members discover...?

Determined to destroy the Sharingan to rid himself of the taste of defeat he received from Itachi, Deidara unleashes his biggest attack, the C4 Karura. Created to kill Itachi, this fierce weapon is capable of destroying living beings from the inside using millions of nano-sized bombs. Can Sasuke escape this attack fueled by Deidara's determination to destroy the Sharingan?

Upon encountering one another, Sasuke and Deidara engage in battle. After exchanging a few blows to test Sasuke's strength, Deidara conjures up his specialty clay dragon and wages long-range attacks against Sasuke from high above. With Tobi's backup support, the battle seems to be going to Deidara.

Under Kakashi's command, the Leaf ninja set off to find Itachi. Using Kakashi's ninja hounds, they gather as much information as they can on Itachi. Meanwhile, the members of the Hebi also scatter to look for information on Itachi. Led by the ninja hound tracking Sasuke's scent, Sakura arrives in town and draws near to Karin.

After hunting down the Four Tails, Itachi and Kisame are summoned by the leader of the Akatsuki. The leader announces the death of Orochimaru to the gathered members and the possibility of his killer, Sasuke, setting his sights on the Akatsuki organization....

Obito ignores Kakashi's order to continue with the mission and leaves to save Rin, who was kidnapped by the Rock ninja. But the enemies detect Obito's arrival and defeat him. Kakashi arrives at the last minute and saves Obito…

"More than ten years ago, the rule of the Five Great Shinobi Nations was destabilized, throwing the world into a conflict later to be known as the Third Great Ninja War. The future Fourth Hokage Minato Namikaze assigns young Kakashi, Obito of the Uchiha clan, and Rin, a medical ninja, on a mission to Kannabi Bridge..."

Slipping past the riot, Sasuke arrives at Jugo's cell. But Jugo refuses to be released, even going as far as to say he rather die a lonely death than to leave the hideout.

Sasuke and his team head for the northern hideout to recruit their next member, Jugo. On the way, Karin explains that the northern hideout is a site for conducting horrific human experiments. A ninja with abnormal homicidal impulses, Jugo is the sole carrier of the enzyme necessary to create Orochimaru's curse mark...

Sasuke and Suigetsu visit the southern hideout to recruit their next member, Karin. Suigetsu is surprised at the hideout's low security level but is told that no prisoners can escape thanks to Karin's abilities. What is Karin's power that allows her to maintain order and an iron defense?

Sasuke has defeated Orochimaru. He then frees Suigetsu, a man trapped inside a water tank, and tells the man to join him. But Suigetsu does not immediately take up Sasuke's offer…

Orochimaru sheds his old body and transforms into a white serpent. As he attacks Sasuke to obtain his body, Orochimaru remembers the time he found the cast off skin of a white snake in front of his parents' grave. Driven by his desire for the Sharingan, Orochimaru finally robs Sasuke of his freedom...

Orochimaru agonizes in pain at his hideout, now requiring level-ten medications just to sustain his body. Even with excruciating pain Orochimaru is preparing for his transference ritual, and Kabuto can feel Orochimaru's further potential. Meanwhile Sasuke also senses the time is coming when he will have to face his mentor...

The Leaf ninja fall back and tend to their wounds. The battle has left everyone with serious injuries. Shizune examines Yuukimaru, who is in a coma, but his body is no longer able to control Three Tails.

Kabuto finally appears before Naruto. Learning that Orochimaru used Guren's and Yuukimaru's feelings for his own purposes, an enraged Naruto enters battle against Kabuto.

Kabuto plots to have Three Tails crush the Leaf ninja by sacrificing Yuukimaru's power and life. Controlled by Yuukimaru, Three Tails' awesome power is about to break free from the seal, when an unexpected ally saves Shizune's sealing team.

With the Three-Tailed Beast readily approaching, the Barrier Sealing team is point to make sure it doesn't surface. However, Kabuto - unwilling to fail Orochimaru - is out to recapture Yuukimaru at whatever the cost...

The Leaf ninja learn that Naruto is inside the Three-Tailed beast. With no other alternative but to trust Yuukimaru's mystical senses, Kakashi and the others follow the boy's guidance and attempt a rescue mission...

To protect Yuukimaru, Naruto and Guren fight alongside each other against the Three-Tailed beast and are swallowed. Inside the beast is an unnatural world filled with limestone.

To protect Guren from the raging Three Tails, Yuukimaru exerts powers beyond his limits. Moved by his action, Guren now comes to regret her past sin of killing Yuukimaru's mother.

Kabuto plans on breaking the Leaf's The Four-Corner Sealing Barrier from the inside by using Yukimaru's power and have the Three-Tailed Beast go on a rampage.

To protect the The Four-Corner Sealing Barrier necessary to seal the Three-Tailed Beast, Kakashi and Naruto wage their deadly battle against Guren. Sai fights a one-on-one battle with Gozu…

The Leaf ninja wish to seal the Three-Tailed Beast, and Guren's team wishes to stop them at any cost. Shizune's sealing team begins their search as they activate the The Four-Corner Sealing Barrier to trap the Three-Tailed Beast…

Reinforcements arrive from Leaf Village. The new mission from Tsunade: seal the Three-Tailed Beast so it won't fall into anyone else's hands and take Yukimaru whose powers are tied to the Tailed Beast into custody.

Naruto enters the mist to seek out Yukimaru. Guren stays alert to protect Yukimaru, whose current situation prevents him from moving. When both sides meet, their emotion over Yukimaru sparks.

Inside the heavy mist, the Leaf ninja manage to rendezvous with Naruto. The team tightens their guard when they learn that the mist surrounding the lake causes illusions. The team discovers that the enemy is after the Three-Tailed Beast, and faced with this unexpected development, Kakashi decides to ask for Tsunade's guidance.

The Leaf ninja use The Bat to pursue Guren. Akamaru and Kiba detect a high level of chakra present at their destination. Convinced something abnormal is about to happen, Kakashi sends Naruto to the lake right before entering battle with the enemy.

Shattering the force field with his newly mastered collaboration jutsu with the toads, Naruto and the reinforcement unit arrive at the battle site. But Naruto's new jutsu is repulsed by Guren's ability to crystallize fluids.

From the results of the analysis of the crystallized Parasitic insects, the enemies currently fighting Kakashi's team are identified as users of the Crystal Style, a rare type of jutsu. Still unclear on what Orochimaru's objective is, Tsunade cannot hide her irritation and anxiety

Team Yamato heads out to provide backup for Team Kakashi. Right before his departure Naruto gets a hint to perfect his new jutsu by entering Gamatatsu's belly.

At the Leaf Village Naruto is busy training with Gamakichi and Gamatatsu. But when he learns that Kakashi and the others are out on a mission to locate Orochimaru's hideout, Naruto rushes to ask Tsunade if he can join the mission.

Staying behind at the hideout, Rinji and Gozu become aware of a shinobi following their tracks. At the same time, Kakashi and his team notice that the enemy is using a bat for surveillance.

Believing Naruto's new jutsu is almost completed, Jiraiya heads off to investigate new information on the Akatsuki's movements. His arm now healed, Naruto returns to the village to continue his training.

Inside Orochimaru's hideout Guren witnesses Sasuke defeating a thousand opponents. Meanwhile, Kabuto and Yukimaru conduct their experiment to summon the Three-Tailed Beast.

Naruto and Jiraiya arrive at the hot springs resort. As an alternative to the Wind Style: Rasen Shuriken, Jiraiya suggests to Naruto the collaboration ninjutsu with a ninja toad.