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Micheletto, Orsini's assassin is recruited by Cesare to defect into the service of Della Rovere who is trying to prove Rodrigo has taken on a mistress.
Extremely ruthless and ambitious cardinal Rodrigo Borgia uses bribery to take advantage of the death of the current Pope and rise to the Papacy.
Rodrigo seeks funds through a profitable marriage for Lucrezia and charges a fee for safe haven; the Borgias host a Turkish prince.