Luka gets some important news, and at the end of the day, an unexpected visitor. A collision between a motorcycle and a car brings critical patients to the ER. Luka and Ray treat the motorcycle rider, and discover a condition his wife wants kept secret. Abby and Neela work on the driver of the car, but his surgery doesn't go well and his wife soon has troubles of her own. Pratt has a new lady in his life, and a new roommate, while Gates has a different kind of girl-trouble. The women of the ER take some time for stress relief.

Luka and Abby treat a man injured after driving drunk, but differ about what should be done when his wife appears to have been abused. Later, Luka receives an unsettling package and Abby meets an intriguing stranger. A group of street kids come to the ER when they think one has rabies, and find a guardian angel in blue. Pratt disappears from the ER for a community-related reason, and learns a surprising truth about a family member. Kerry's TV appearance becomes a real emergency.