A belligerent young man with flu symptoms presents a challenge to Morris and Sam when he refuses treatment. Luka and Abby's childcare emergency means balancing baby care with patient care in the ER until a nanny can be found, but the candidates prove less than satisfactory. Luka has an uneasy encounter with Curtis Ames at the hospital, and later Abby and Baby Joe have a "chance" encounter with Ames at the park. Pratt discovers a local church's risky drug exchange program. Neela and Gates square off at an M&M.

It's Thanksgiving in the ER, and everyone prepares for the festivities. Luka and Abby's shared feast is delayed when a medical evacuation flight to transfer an older patient puts Abby in the middle of a bus crash scene where she earns the respect of the flight crew. Luka shares concerns about a worrisome former patient with the police, who have doubts about what he thinks is happening. Pratt turns to Kerry after learning about Chaz, and Gates tries to charm Neela, but Meg adds a sour note