Malucci and a female paramedic become trapped in an elevator with a man who is vomiting blood. Malucci saves the man's life and celebrates by having sex with the paramedic in an ambulance, which ultimately results in his dismissal by Weaver. Abby move's out of Luka's apartment and accidentally breaks his fish tank on the way out. Chen treats an abandoned infant with a birthmark in the shape of the sign of the Virgin Mary. Meanwhile, the strain of motherhood may be catching up with Corday when she falls asleep during surgery.

Weaver prepares to call her birth mother, while she treats a man who was accidentally run over by his daughter while she was drunk. Susan's first day back is typically hectic, as she treats a girl with an ectopic pregnancy who refuses to stay for treatment and a man faking a coma to escape his bookie. Abby seems to notice the chemistry between Susan and Carter and gets a little jealous. Cleo has gotten a better job 40 minutes outside of Chicago. The Greene household is pretty crazy now that Rachel is living there. After Elizabeth loses another patient to a post-op infection, an investigation is launched and someone is assigned to shadow her all day to check her cleanliness. Benton panics when Roger reveals that he can't find Reese--it turns out that Jackie picked him up from school after he got in a fight. Carter's day as chief resident is marred a little when his grandmother comes to the ER after slipping.