After finishing a shift, Carter approaches Weaver about an attending position, and then gets sucked back into work when a stampede at a rock concert brings in many patients. Abby and Luka break up. When Weaver goes MIA, Malucci and Chen make a severe mistake with a patient, ultimately leading to the patient's death. They blame it on Weaver for not answering their pages; we later see that Weaver left her pager in the bathroom at Doc Magoo's. Carla and Reese get into a car accident, which kills Carla and injures Reese. Mark and Elizabeth struggle to balance parenthood and their schedules.

Susan Lewis arrives in Chicago to interview around town and have lunch with Mark. She gets reacquainted with the nurses and Carter, meets Elizabeth, and is later offered an attending position by Mark. Weaver and Chen clash over a risk management meeting, and ultimately, Chen quits. Mark and Elizabeth treat a six-year-old Edwards Syndrome patient whose parents abandon him while he is in surgery. When Benton becomes stuck in surgery he must resort to calling Roger to pick up Reese.