Three weeks after the death of Derek Fossen, Greene faces interrogation at an M&M conference. However, Corday is the only one to suspect something wrong. Meanwhile, Carter's parents return to town for his grandfather's funeral, which Abby briefly attends. Abby has decisions to make; Luka wants her to move in with him. Weaver returns from an impromptu vacation, worried that Romano has outed her to the staff. Chen is the new chief resident. Benton deals with Cleo's meds and Jackie's problems adjusting to life after Jesse's death. The ER is filled with patients after a brawl at a talk show taping.

Malucci and a female paramedic become trapped in an elevator with a man who is vomiting blood. Malucci saves the man's life and celebrates by having sex with the paramedic in an ambulance, which ultimately results in his dismissal by Weaver. Abby move's out of Luka's apartment and accidentally breaks his fish tank on the way out. Chen treats an abandoned infant with a birthmark in the shape of the sign of the Virgin Mary. Meanwhile, the strain of motherhood may be catching up with Corday when she falls asleep during surgery.