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Ryan feels obligated to repay his sister's help, however inappropriate, and therefore must shortly hand Wilfred into Darryl's daycare. The dog feels neglected and behaves strangely depressed.
Ryan gets his wallet back (that's the good news) when his malevolent, porn-addicted neighbor Spencer (Ethan Suplee) shows up. The bad news: Spencer's looking for answers about who broke into his house. He's also looking for blood.
Ryan and Wilfred volunteer at a hospice and discover Wilfred may have a remarkable secret talent.