Ryan ignores Wilfred's advice, creating an existential crisis for both of them.

Just as Ryan finds happiness in his life, Wilfred begs him to sacrifice it for a larger purpose.

Ryan begins to suspect that his friendship with Wilfred may be self-destructive.

Wilfred uses Ryan's unhealthy habit of isolating as a means to rid himself of a neighborhood pest.

Ryan's resentment of his eccentric mother is exacerbated when Wilfred starts treating her like the mum he never had.

Ryan has a guilt complex over the death of his childhood dog, and Wilfred, upon learning of it, goes to otherworldly lengths to help Ryan discover the truth about how the pooch passed on. Meanwhile, Kristen throws a party for her boss.

Wilfred's pursuit of a new love interest forces Ryan to swallow his pride - among other things.

Wilfred persuades Ryan to help him get rid of Jenna's boyfriend.

Ryan and Wilfred volunteer at a hospice and discover Wilfred may have a remarkable secret talent.

Ryan feels obligated to repay his sister's help, however inappropriate, and therefore must shortly hand Wilfred into Darryl's daycare. The dog feels neglected and behaves strangely depressed.

Ryan gets his wallet back (that's the good news) when his malevolent, porn-addicted neighbor Spencer (Ethan Suplee) shows up. The bad news: Spencer's looking for answers about who broke into his house. He's also looking for blood.

Wilfred comes into Ryan's yard, so the two go to the beach, as Wilfred has always wanted to swim in the ocean. After Ryan lets him, the two bond more, and spend the day hanging out. When Ryan drops Wilfred off, Jenna asks Ryan to trick Wilfred into going to the dentist to get his teeth cleaned. Ryan reluctantly accepts, and tricks Wilfred by telling him they're going to the movies, and Wilfred is mad at Ryan. While under anesthesia, Wilfred reveals a horrifying secret about Jenna.

After a failed suicide attempt, Ryan notices that he sees the neighbor's dog as a person dressed dog costume.