Christian searches for immortality and Kimber reacts to the news of Liz and Christian getting married. KATEE SACKHOFF, ANNALYNNE McCORD and JOHN SCHNEIDER guest star.

Christian makes arrangements to secure his family's future after he's gone. Liz prepares for the wedding. Recurring guest star KATEE SACKHOFF appears as Teddy.

Sean and Teddy (recurring guest star KATEE SACKHOFF) explore their relationship and Christian relates to a patient with a unique condition.

Sean's hiring of a new anesthesiologist leads to trouble. Kimber goes to extreme measures. BRADLEY COOPER, MORGAN FAIRCHILD and KATEE SACKOFF guest star.

Matt gets jealous when Sean and Raj (recurring guest star ADHIR KALYAN - "Aliens in America") start to develop a father/son relationship. Christian and Liz try making things work.

Sean tries to deal with his feelings for Julia. Christian meets someone who gets what he is going through. PORTIA de ROSSI, JENNIFER COOLIDGE and ANNALYNNE McCORD guest star.

Christian and Liz grow closer when his chemotherapy makes him ill and she becomes his caretaker. Sean reconnects with his broken family.

Sean's physical and emotional well-being is greatly impacted after he survives the attack from Colleen (SHARON GLESS). Meanwhile, Christian gets some troubling news.

Tragedy strikes the McNamara/Troy family after Julia learns what has caused her ill health. A visitor from Christian's past brings some revealing news. And Sean finds the price of fame to be more expensive than it's worth.

A television critic gives Sean a dose of the ugly side of Hollywood. Meanwhile, Matt experiences a special bond with one of Christian's patients. And the cause of Julia's ailing health is uncovered.

Eden looks to Sean for help after getting into business with Kimber and Ram. A group of wealthy socialites hires Christian for all of their cosmetic surgery needs. And Sean discovers another side of Colleen.

Christian attempts to cope in the aftermath of a death. Meanwhile, Colleen feels threatened when another talent agency shows interest in Sean's acting career.

Special guest stars include Oliver Platt as 'Freddy Prune,' Bradley Cooper as 'Aidan Stone,' Jessalyn Gilsig as 'Gina Russo' and Sharon Gless as 'Colleen Rose.' Guest stars include AnnaLynne McCord as 'Eden Lord,' Marlee Matlin as 'Barbara Shapiro' and Paula Marshall as 'Kate Tinsley.' Written by Hank Chilton. Directed by Craig Zisk.

As Julia's health worsens, Christian falls back into old habits. Sean hires Gina as the new McNamara/Troy receptionist in order to get back at Christian. Meanwhile, Dawn Budge returns for cosmetic surgery after another unfortunate incident.

Sean confronts Christian and Julia about the secret they have been keeping. Meanwhile, a hospitalized Matt bonds with his rehab counselor, and Eden tries to bond and make peace with Julia. Kimber reveals her plans for the future.

As Sean tries to regain his youth through his relationship with Eden, a violent and traumatic event causes Julia to question her relationship with Olivia. Meanwhile, in an effort to better her life, Kimber makes a decision that devastates Matt.

Christian, jealous over Sean's newfound fame, convinces Sean to tape a reality show based on their careers as plastic surgeons. However, no one expects the drama that unfolds when the cameras roll.

While a patient inspires Sean to take his relationship with Kate in a new direction, Eden uses extreme methods to persuade Christian to perform surgery on a friend. Kimber and Matt fall on hard times.

A series of unfortunate events unfold for an unlucky Dawn Budge, who seeks reparative surgery from Sean and Christian. Meanwhile, Annie and Eden start to form a sisterly bond, which unnerves Sean.

Sean and Julia learn more about their family dynamics as Sean resists Eden Lord's advances. Kate reveals a secret compulsion. Matt comes to Los Angeles with some troubling news for his fathers.

Sean and Christian learn about the glamorous side of fame and the price that people are willing to pay for it. Julia visits Sean, Christian and Liz in Los Angeles with a surprise announcement.

In the fifth season premiere, Sean and Christian settle into their new plastic surgery practice in Beverly Hills and struggle to build it from the ground up. New opportunities arise after they meet a slick Hollywood publicist.