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During a dark moment in his life, Sheldon finds happiness with a new woman. Meanwhile, he becomes increasingly suspicious about his patient Nick's involvement in Sarah's disappearance.
In an episode told from Cooper's point of view, we follow him from the moment of conception through a nasty fight with Charlotte, which inadvertently threatens the lives of their triplets. Meanwhile, Violet comforts a friend who is being advised to take her partner off life-support.
Charlotte stresses the doctors out when she continues to run Saint Ambrose Hospital from her doctor-ordered bed rest. Meanwhile, scared that Charlotte might never leave the hospital, Mason begins acting out in school.
Violet has to adapt to a new way of life, Sheldon tries to deal with his illness and Charlotte is given some unwelcome news.