After Eric receives good news about his heart, the Colonel and Ruth decide to give him and Annie an RV as a gift. As a result, they decide to take the family on a cross-country trip in it. Upon hearing their news, Lucy starts to panic because she and Kevin were planning on taking on jobs in Crossroads. Lucy then decides to invite herself, Kevin, Savannah, Sandy, and her boyfriend along on their adventure.

Eric and Annie rush to the hospital after Eric wakes up with a good feeling about his heart condition. Unsure whether her parents are at the hospital due to good news or bad news, Lucy is a bundle of nerves, and it's up to Kevin to keep her thinking positively as they wait for news. T-Bone and Ruthie decide to get back together, but Martin hopes to change Ruthie's mind when he reveals that he's in love with her as well.

With plans for another child, Lucy tells Kevin that it might not be a good idea to move so far away from the rest of the family. T-Bone confides to Eric that he's having second thoughts about breaking up with Ruthie, who is spending all of her free time lately with her former crush, Martin. Sandy's boyfriend surprises her with a marriage proposal, and T-Bone's estranged father shows up on the Camdens' doorstep.

Ruthie gets a text message from what she thinks is T-Bone breaking up with her. But the truth behind the matter is a bit different. Meanwhile, Lucy and Kevin try to decide whether or not they will relocate to Crossroads.

When Lucy gets an unexpected job offer in a small town known as Crossroads, she and Kevin take a trip out there to see if they might consider making the move. Back in Glenoak, Ruthie learns that removing her tattoo will not be an inexpensive procedure, and after getting no sympathy from her parents, she tries "guilting" T-Bone into paying the bill.

When small things happen, some Camdens see them as signs. Lucy and Eric both cross paths with a black bird. They both come to the conclusion that this is a sign, and a bad one at that. Meanwhile, Ruthie gets a sign on her own. When she loses a diamond in the ring that T-Bone gave her as a promise to get engaged someday, she thinks that this is her sign that maybe being with T-Bone is not the best choice.

Ruthie tries to hide her tattoo from her parents, not realizing that they already know something is up with her. Lucy knows about the tattoo, but she has a very specific reason for keeping it to herself. As it turns out, most of the Camdens have dirty little secrets that they would rather not reveal.

Sandy starts falling for a handsome doctor, and Martin may not be able to handle it. Elsewhere, T-Bone and Ruthie want to do something romantic for Valentine's Day, and they profess their love for each other in an unusual way. The Colonel and Ruth drop by unexpectedly, prompting Lucy and Kevin to leave town, and Eric fears that his parents know about his health problems.

Ruthie insists that T-Bone get his driver's license so they can go away for privacy; unfortunately, T-Bone makes the mistake of asking Kevin to help him get ready for the test. Lou informs a stunned Eric that the church deacons feel he and Lucy are no longer appealing to the younger church members, so it is suggested that Sandy deliver the next sermon. Mac gets a job at the movie theater so he can afford an apartment with Jane and Margaret.

Eric and Lucy tell everyone that they are going out of town on "official church business," which is not exactly true, while Annie and Kevin seek the truth about their spouses' little white lies. Meanwhile, Sandy takes over Lucy's teen class for the day, and Ruthie will do anything to prove that she is not a little girl anymore.

When Ruthie and T-Bone work on a school assignment about the genocide in Darfur, they get the whole Camden family, and the community involved in the cause.

Eric suddenly finds himself in heaven, quite literally, when he runs into several people who have gone before him, particularly Annie's late mother. Meanwhile, the family becomes nervous when Eric does not come home from work, and Annie tries to hold everyone together. Could he soon be headed to the pearly gates himself?

Eric takes a new approach to counseling members of the church. T-Bone stuns Ruthie by telling her what he really thinks of her selfish and obnoxious attitude, then ending their argument with a kiss.

Eric, Annie and Ruthie are on their way home from Scotland, but they are held for questioning at the airport after Ruthie makes an unusual comment. Elsewhere, as a favor to Martin, Mac seeks information about Sandy's feelings for Simon. Lucy does her best to stay strong for the whole family as the truth about her father's health condition comes out.

Ruthie is informed of her father's health prognosis when her parents show up in Scotland, but she shocks them by reacting with very little sympathy or understanding. Sandy calls off her marriage plans with Martin after his best friend questions why they are in such a rush. Back at home, Lucy steps up as a much-needed source of stability for her younger siblings, as well as T-Bone, who needs help making a dramatic decision.

Ruthie is nervous when she finds out that her parents are heading to Scotland. She reveals a very unattractive side of herself when she openly admits that she is not about to sacrifice her own freedom and happiness to come home and be with her sick father. Kevin has a difficult time helping Lucy come to grips with Eric's illness. Sandy accepts Martin's marriage proposal just to get rid of her clingy boyfriend. Kevin finds out a secret about Jane.

When the paramedics are called to the house, Annie realizes that Eric has been hiding his health issues from her, even though he insists he is fine. Meanwhile, Lucy contemplates having more children after visiting with Sandy, who has problems of her own when she must choose between the two guys in her life.

Eric makes yet another decision without consulting his wife, who finally comes home to some drastic changes in the house. Elsewhere, Sandy finds herself in a romantic triangle with Martin and a guy from school. Eric meets three homeless teens and gives them a place to stay—in his and Annie's home.

Eric continues to manage the household in Annie's absence. He begins home-schooling the twins and finds even more stress added to his life when their third grade teacher shows up at the house, eager to start a relationship with him. Meanwhile, Kevin and Lucy start noticing Eric's strange behavior, but their attempts to uncover the truth only make matters worse.

Mary has recently given birth to twin daughters, so Annie heads off to Buffalo to help her out. Eric is left to take care of things at home. A difficult issue with the boys' teacher prompts him to pull them out of school without consulting Annie, and an excruciating physical pain in his neck isn't helping matters. Kevin's brother Ben arrives for a visit, but there is only one way they can convince an emotionally unstable Lucy to let him stay with them for a little while.

Tension mounts in Kevin and Lucy's marriage as Lucy pulls away from him emotionally, spends increasing amounts of time at the movie theater, and even starts pouring her heart out to a teenage boy who works there. Back at home, Annie encourages Kevin to not give up on Lucy. Eric is less than thrilled with the new name that his twin sons have given him, but it is nothing compared to a little run-in that he has with their very young third grade teacher.

Strenuous events impact all the Camdens as Kevin and Lucy cope with an unexpected tragedy in their young lives. Matters worsen when Lucy convinces her father to let her deliver next Sunday's sermon while she is still in an emotionally unstable condition. Martin frustrates Sandy by suggesting that they get married and build a family for their infant son, then becomes angry when he realizes why Sandy is really holding back. Ruthie is studying in Scotland for the time being, and Annie can't shake the feeling that something is terribly wrong with Eric.