When an unknown Hispanic boy is abducted in plain sight from a Spanish Harlem street, Jack and the team are perplexed as to why nobody comes forward to report him missing. During the course of the investigation, Martin is pushed to breaking point, compromising both Vivian and himself.

The team search for an intensely driven neurosurgeon, Dr. Lianna Sardo, who disappeared after a late-night jog in the city with her ex-husband. Triggered by aspects of the case, Samantha struggles to balance her own loyalty to her job with her feelings.