Both born with brittle bone disease, Dejua and Antwon have suffered over 600 breaks between them. Robert's spine is not connected to his hips.

The family of conjoined twins, Callie and Carter, must decide whether to separate the sisters. Josh shares his life as 'The Tourette's Barber'.

After having her leg amputated, Jillian has surgery which will allow her to use her ankle as her knee. Ashley's condition turns her muscles into bone.

Natalia was born with a rare condition referred to as the 'vanishing bone disease'. Sanja has a condition that causes blisters to form on her skin.

Natalie suffered major, life-changing burns after a bonfire explosion. Now, aged 18, she's not letting her burns hold her back.

Ravi receives life-changing surgery to remove the huge tumours that cover his face. Lauren has 24-hour treatment to prolong her life.

A man whose life changed for ever when surgeons removed a large piece of his skull and a woman with a rare condition that means she grows skin 10 times faster.

After 22 surgeries and losing his right eye, Amit refuses to let his incurable neurofibromatosis define him. Mari Jade suffers from daily fits.

15-year-old John suffers from epidermolysis bullosa and has no indication of how long he might live. Justice suffers from a rare sleep condition.

The stories of people who suffer from rare and mysterious medical conditions. Some need surgery so complex that the odds of survival are slim.