When an exotic animal keeper vanishes on her way to work at San Diego's Wild Animal Park in the fall of 2000, investigators unearth several suspects, but only one who had ample opportunity to go in for the kill.

A spree killer who leaves his victims tied up with neckties torments the men of Atlanta in the fall of 2002; as investigators hit many dead ends, one clue left behind could be the final puzzle piece detectives need to tie these cases together.