In 2001, a massive explosion decimates a home on a quiet Scottsdale, Ariz., street; the bodies of three family members lie amid the rubble, but one key person is missing, and the search goes on for decades.

In 2003, a lively college town in Kentucky faces tragedy after the vicious rape and murder of student Katie Autry; as police sift through the suspect list, two people stand out from the rest; one learns if they play with fire, they will get burned.