Sam is determined to find out how Dr. Sachs is able to pinpoint time of death so precisely, even if it means several convictions are overturned. A mother changes her plea to guilty, but Leo is still not satisfied that they have the truth. A loving daughter draws a picture for her prisoner dad that brings a confession. Dr. Sachs is found to have violated professional ethics, but what will serve the cause of justice best?

Questions about a celebrated pathologist's accuracy in past cases leads to several exhumations; Sam Ryan is assigned to reexamine the remains. One particularly brutal murder conviction depends on the time of death being precise. Two crucial witnesses are found: one on her deathbed, anxious to get something off her chest, and the other dead behind a remodeled wall.

Sam Ryan steals a toothbrush to get the DNA of the father of the unborn child of a suspected suicide. Tangled relationships between an athlete and his family are amplified when his body is found hanging in her apartment. Police arrest the athlete's brother-in-law after an anonymous tip. Harry's attempts at determining time of death by the growth of maggots give a wrong answer.

A John Doe is found months after his death; an attractive female agent for a championship athlete is believed to have jumped to her death from a rooftop. Forensic pathologists must sort out time and methods of death.

Sam and Leo, colleague Pathologists, are on opposing sides of a high-profile court case.

Sam comes under intense scrutiny during an official inquiry into the deaths of two brothers while they were in prison. Her findings are soon challenged by her colleague, Leo Dalton, who is brought in to perform a second autopsy. Meanwhile, a series of murders that are taking place cast suspicion on a recently released ex-convict. He served years in prison after being convicted of killing his wife; the evidence against him was given by Sam during one of her very first cases. During his time in prison, however, he continued to deny his guilt. Sam begins to believe that someone is stalking her, while the police have trouble locating the ex-convict.

In a suspected terrorist attack on a London hotel a government minister is killed. As Sam and the team investigate the case, old friends and government officials soon muddy the water.