In Baton Rouge, a brawl erupts in the back of Meghan and Dee's ambulance when an overdose patient wakes up swinging. Meanwhile, Ariel and Cunningham fear the worst as they rush to the scene of a flaming motorcycle wreck in Yonkers. And in Austin, when a truck swerves out of control, Kim and Audrey hope to find its missing driver at the bottom of a ravine.

The opioid epidemic grips the nation as Baton Rouge EMS teams scramble to save lives. A heatwave in the south makes bad calls worse when a man passes out from heat exhaustion and needs intervention before his internal organs shut down. Meanwhile, in Yonkers, Patrick prepares to deliver a baby in the back of the ambulance when an expectant mother's contractions are only 3 minutes apart.