The 10-episode series follows EMTs as they tackle emergencies on every level, bringing viewers along for the ride while also experiencing the high intensity environment of the call centers. The series follows EMTs as they treat a stroke victim in Yonkers and a heroin overdose in Baton Rouge. They also are faced with a malfunctioning internal defibrillator in Tucson and a six-car pile-up that requires multiple ambulances in Austin.