EMT's in cities across America answer the calls for help from their communities. In Austin, Texas, responders run point in a massive multiple car collision and need to triage more victims than can fit into their ambulance. A combative addict and an overdose gone wrong offer tough challenges in Yonkers, New York, while in Baton Rouge, Louisiana, southern charm is revealed to have its own healing effects. And in Tucson, Arizona, responders do everything they can to avoid delivering a baby in the back of their ambulance.

Yonkers first responders Alex and Jamal face unexpected challenges when they respond to a call for a man with a broken ankle who fell from a fire escape. The night really starts to heat up for Steven Lopez and Sam Netheron in Tucson when they are called to a structure fire and must search inside for possible victims. Things get personal for Niki Johnson in Baton Rouge when a call for a patient with back pain takes an emotional turn.