The opioid epidemic grips the nation as Baton Rouge EMS teams scramble to save lives. A heatwave in the south makes bad calls worse when a man passes out from heat exhaustion and needs intervention before his internal organs shut down. Meanwhile, in Yonkers, Patrick prepares to deliver a baby in the back of the ambulance when an expectant mother's contractions are only 3 minutes apart.

Patrick and Danelle from Yonkers, New York, go above and beyond to help a schizophrenic patient who's had a hard time being taken seriously in the past. Far away in Austin, Texas, Holly and Chris have a scary run-in with poison control involving a nervous mother. Meanwhile, Baton Rouge, Louisiana, has a busier than usual night with erratic patients, culminating with one of the medics saying, "Only on the night shift."