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Gary and Chuck must stop an old friend of theirs from their former job from having a fatal plastic surgery to impress his girlfriend and enhance his career.
Gary must help a young boy who is ill with leukemia, but is refusing treatment. Gary wants him to meet Jenny Sloane, Chicago's sweetheart who is ill with cancer. A Sun Times columnist writes a column about Jenny Sloane.
Gary and Chuck become involved with a basketball program at a local church for inner city youth, where they meet a young nun named Sister Mary. Gary helps Sister Mary from abandoning her call after a young man involved with the basketball program is killed during a convenience store holdup, which Gary fails to stop.