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A crooked D.A. has aspirations to be Mayor of Chicago, and is holding hearings about police corruption as a way of getting there, focusing on Lt. Crumb's partner who has taken bribes in the past. Crumb's partner steals a portion of the money he and Crumb are using in a sting operation, leaving Crumb holding the bag. The D.A. dislikes Crumb anyway, and proceeds to frame Crumb for the missing money, three weeks before his retirement. Gary tries to help Crumb, but he is his usual obstinate and cranky self.
After learning that a leader of a racist movement will be assasinated during a march, Gary begans to debate whether he should save his life or let him die. Marissa manages to convince him to save him, but the dilemma is further compromised when the leader's comrades attack and vandalize McGinty's. Now Gary has to stop the sniper from killing the leader of the movement. The situation is further complicated when the leader's son befriends a young African-American kid.
The newspaper arrives with an article written in Russian. Gary saves a cab driver, in a seemingly unrelated article written in English. The cab driver is able to read the Russian article to Gary. Gary then must save a beautiful Russian violinist from being murdered and brings her together to her long lost father.
Gary and Chuck become involved with a basketball program at a local church for inner city youth, where they meet a young nun named Sister Mary. Gary helps Sister Mary from abandoning her call after a young man involved with the basketball program is killed during a convenience store holdup, which Gary fails to stop.
Gary and Chuck must stop an old friend of theirs from their former job from having a fatal plastic surgery to impress his girlfriend and enhance his career.
Gary must help a young boy who is ill with leukemia, but is refusing treatment. Gary wants him to meet Jenny Sloane, Chicago's sweetheart who is ill with cancer. A Sun Times columnist writes a column about Jenny Sloane.
McGinty's is asked to cater the wedding of Gary's ex-girlfriend, his high school sweetheart. Her romantic feelings are still somewhat directed at Gary, and what's worse, her father has been under police's witness protection for three weeks and the paper warns of criminal and violent actions at the wedding.
Gary must help a Vietnam vet who has the Congressional Medal of Honor when a ceremony in his honor triggers feelings of guilt because of a mistake he made in Vietnam.
Gary's hotel room burns in an electrical fire. While wondering where he is going to live, Gary also finds out that a greedy businessman wants to purchase McGinty's and an orphanage in order to demolish them and build a parking lot. Gary and Chuck must save McGinty's and the orphanage, and Gary must find a new place to live.