Amélie has been stabbed and every evidence points to Véronique. While she is sent to prison, her family - with Lars in particular - start looking for clues to prove her innocence. But as months go by, Véronique starts to doubt herself and decides to confess. Marie-Rose returns from France to support her daughter and has serious confrontations with both Amélie and Brigitte. Marie still wants to have her revenge on Lars and Véronique and starts a relationship with the 18 year old Cédric. When Lars is certain that Marie knows more about the murder attempt, he and Evy start an investigation, but Marie goes to great lengths to hide her secrets.

Benny comes in contact with Jonas, who just recently was released from prison. It turns out that he is the brother of Robyn and both Benny and Jenny want to reunite brother and sister. Meanwhile Jenny and Jan start an intimate friendship but decide that they should leave it at that.

Mathias is still waiting for his fiancé Veronique, but will she marry him or will she run away with Lars? Stefanie has been rescued from her kidnapper, but will she eventually remember that Simon is behind it all? Jan wants to divorce Linda, but when she tells Jan about her brain tumor, he might reconsider his decision. But what about Viv?

June Van Damme was found murdered in her office at VDB Fashion. Police inspectors Mortier and Delaet open their investigation but soon discover that June had a lot of enemies. Who shot June?

Junes actions to murder Peter have failed but together with her sidekick Stan she continues to terrorize the entire family Van den Bossche. Marie-Rose divorces Mathias after his affaire with Trudy and leaves the country to start a new life. Meanwhile in the USA, Bart Van den Bossche had to fake his own death to escape from the Italian maffia.

With the financial aid of June Van Damme, Veronique was able to start her own company: Vero Bello. Thomas Feyaerts makes his entrance as the long lost grandson of Jan Van den Bossche. Maarten continues to search for Roos and is willing to go very far to get his love back.

Rita finally has her alcohol addiction under control, but will the family forgive her once again? Leen has given birth to her son Arthur, but she soon breaks under the pressure of single motherhood. At VDB Fashion, Peter and Veronqiue clash about the management of the company.

Caroline De Meester died during her fight with Marie-Rose and the police investigates her involvement. A brand new family makes its entrance with grandfather Patrick, his daughter and son-in-law Liesbeth and Benny and their children Arno and Stefanie.

Rita Van den Bossche is facing a large trial concerning her involvement in the fire at VDB Electronics and the murder of her ex-husband Rob. Peter and the entire family believe in her innoncence and look for evidence to get her free.

The wedding of Peter Van den Bossche and June Van Damme has a happy ending. Marie-Rose breaks completely with her son because she doesn't want to accept June to the family. Els makes the difficult decision to move to Cyprus for good.

Now that Xavier Latour fell of the roof of his apartment, the family can continue with their own lives. Peter copes with the drug addiction of his wife Trudy, while falling in love with business woman June Van Damme. Mieke Van den Bossche divorces Wim after he finds out about her affaire with Paul, the soon-to-be-husband of her sister Leen.

Three years later. Walter has passed away from AIDS leaving a grieving grandmother Anna, who is now temporarily in a wheelchair. Walters son Kobe suffers from his death and develops a personality disorder, resulting in multiple assaults and rapes of his closest female friends. Mieke has moved on from the loss of Marc and Lennart and marries the son of her good friend Gaston. Jan and Linda struggle with the cost of two young adults, with Leen studying to become a doctor and Maarten finding his passion in cooking. Peter goes into business with shady foreigner Graham Boardman, who soon turns out to be Xavier Latour. Bertje Van den Bossche returns from China and has become a very succesful businessman with the help of his new girlfriend Cixi. Veroniques son Cédric gets leukemia.

Tragedy is just around the corner in this new season of Familie. Didier De Kunst has hired a dangerous mercenary to murder his enemy Guido Van den Bossche. He eventually strikes at the opening of the Peter Van den Bossche Plant in Malta, but only Claire dies while Guido survives. He ends up in a wheelchair and falls in love with his personal nurse Els. Rita has started a new live in Spain with her son. Herman and Ingrid decide to sell their pub and move to Spain to be close to Pierrot.  Mia and François enjoy their trip around the world, but the family at home receives disturbing news about a deadly plane crash. For the first time in the history of Familie, there is a big time jump of 7 years. Jan and Nele became the proud parents of Leentje and Maarten while Veronique is now the new CEO of VDB Systems. When Bart returns from the States to claim his rightful place in the company, Veronique starts working with Didier to eliminate her new enemy. When Guido and Els get married, their reception is brutally disturbed by a group of terrorists, threatening to blow up the entire building...

The members of the cult La Torre Blanca have committed suicide, but Peter is nowhere to be found. In a series of mysterious letters, he lets hit family know that he will soon come home, but his friends find him dead in Cuba. Marie-Rose recovers from her serious injuries while Rita has to adjust to her new life in prison. Her newborn son Pierrot ends up in the care of foster parents Herman and Ingrid and when Rita is released from prison, she has to face a serious trial while also fighting for her son. Walter falls in love with his housekeeper Carine and has to choose between his faith in the church and the love of his life. François and Mia get married and Jan and Nele are expecting their first child together.

Guido wants to take his life back in hands and starts a completely new company to compete against Didier De Kunst. Meanwhile his son Peter travels to the States to study at Harvard, but some unexpected encounters and love troubles take him down a dark road that eventually leads to a dangerous cult in Spain. Veronique moves to Italy to live with her new husband Giancarlo and both Marie-Rose and Guido start a new life after their divorce. Rita is once again the troublemaker of the family after she learns about her pregnancy. She finds solace in alcohol and starts terrorizing the entire family...

Times are not great for the Van den Bossche family. Guido has been kidnapped and the situation gets worse every day when more details of his disappearance come to light. A large investigation from the police, uncovers the alleged corporate espionage at FAIC, the company of Didier De Kunst and Guido's biggest competitor. One by one, people lose their faith in Guido's innocence and Didier is able to buy a majority of the shares of VDB Electronics, making it a child company of FAIC. Marie-Rose finds solice with her lawyer and good friend Jean-Michel Le Croix. 

Marleen was killed by a car when crossing the road, leaving Ben to take care of their adoptive child Lovely. Anna and Albert help when needed, but tensions rise when Anna gets too close to the situation and starts to distrust Ben and his ability to take care of Lovely. The result is not very positive. Ben loses the custody of Lovely and she is sent to a foster family. Ben decides to move to Africa. 

A traffic accident has several consequences for Guido and his family. While he has a long recovery ahead, Veronique loses her unborn child and Marie-Rose goes to VDB Electronics to claim her place as the CEO of the company. When Guido is able to return, Marie-Rose decides to start her own company with the help of business partner Gerard Van de Caveye. Fashion house Maison Marie-Rose is born. Peter has his own problems when facing a trial after the alleged abuse of his best friends girlfriend Birgit. When he is found not guilty, Peter decides to start a career in the military. 

Rita loses her second son and moves with Dirk to the United States. When he cheats on her with several women, Rita returns to Belgium a broken woman. She looks for solice in alcohol and gets institutionalized after a suicide attempt. 

The flirting attempts of Babette result in a divorce between Jan and Monique. While Babette moves on with Peter, Jan loses his home and children and Monique decides to make her life better by opening her own restaurant. She soon meets businessman Didier De Kunst, who happens to be Guido's biggest competitor.

Elsewhere, new love finds a way in the family. Anna meets widower Albert Thielens and the two get married. Marleen wants to start a family with school teacher Ben Van der Venne, but they have to think about adoption to have their own child. Francois Van den Bossche - the only brother of the deceased Pierre - has to deal with the dementia of his wife Simonne and eventually sends her to a nursing home.