Katrina has oozing, smelly boils that have taken over her life. Kim's head-to-toe tumors interfere with her sleep apnea mask, resulting in constant exhaustion. Dr. Lee and a medical student trainee help Emil and his wife, who are afraid the bump and lesion on his back might be cancerous.

Dr. Lyndsey assists Dr. Lee with Lance's notoriously big bump that halted his rap dreams. Shelby has lost control of her sweet tooth, her health, and the mystery bumps she has developed. Dr. Lee proposes a long-shot cure for Jante, who has been losing pigment in her skin as well as her confidence.