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John is bound to a wheelchair and ready to give up after his legs have become too swollen, painful, and smelly. Chad's painful, giant hip growth. Dr. Farhang helps Dr. Lee with John's large cheek growth.
Tana deals with an abusive past, and a forehead bump. Ernestine, a die-hard Yankees fan, has a huge, misshapen growth on her back. Dr. Lee teaches eager dermatology intern Dr. Hannah Tolson how to remove Foday's mystery bumps named Mama and Baby.