John is bound to a wheelchair and ready to give up after his legs have become too swollen, painful, and smelly. Chad's painful, giant hip growth. Dr. Farhang helps Dr. Lee with John's large cheek growth.

Tana deals with an abusive past, and a forehead bump. Ernestine, a die-hard Yankees fan, has a huge, misshapen growth on her back. Dr. Lee teaches eager dermatology intern Dr. Hannah Tolson how to remove Foday's mystery bumps named Mama and Baby.

Jeana has huge, spherical growths dangling from her ears. Alondra owns a flower shop but her painful, hydrangea-sized back bump prevents her from helping customers. Dr. Lee shows Dr. Lyndsay how to avoid the Danger Triangle.

Dave has 17 huge, painful head bumps. Melissa recently moved to a new town but her mysterious red, scaly lesions cover her legs. Glamorous dermatologist Dr. Shearer Seymour shadows Dr. Lee as they attempt to remove a pointy cyst from Sam's cheek.

Angela has a huge, melon-sized growth on the back of her neck that she fears will ruin her daughter's wedding, and her daycare business. Loretta is terrified that her painful, oozing skin condition will get in the way of making her movie.

John is a sweet guy trying to get over his bumpy past; Tami has yellow deposits on her eyelids that make it impossible for her to feel beautiful; Dr. Farhang helps Dr. Lee with a terrified patient, Lili, who has a lump on the back of her arm.