Dave has 17 huge, painful head bumps. Melissa recently moved to a new town but her mysterious red, scaly lesions cover her legs. Glamorous dermatologist Dr. Shearer Seymour shadows Dr. Lee as they attempt to remove a pointy cyst from Sam's cheek.

Tana deals with an abusive past, and a forehead bump. Ernestine, a die-hard Yankees fan, has a huge, misshapen growth on her back. Dr. Lee teaches eager dermatology intern Dr. Hannah Tolson how to remove Foday's mystery bumps named Mama and Baby.