Bobby blames himself for his brother's death. Five years later, tragedy strikes again.

Jack and Jackie suffer the loss of their newborn child; she and JFK are in Dallas on that fateful day in November.

The Cuban Missile Crisis brings America and Russia to the brink of war. Jackie leaves JFK after one infidelity too many.

Riots over desegregation in the South force JFK to act. Jackie's use of amphetamines continues. Joe Sr. suffers a stroke.

The Russians build a wall separating East and West Berlin while Bobby prepares to go after Sam Giancana.

When the Bay of Pigs invasion proves disastrous, JFK makes a difficult decision he must later atone for.

The Presidential election comes down to the wire; Bobby tells Joe Sr. he's leaving politics.

The Kennedys rally to put Jack in the White House but their difficult past illuminates a deeper struggle.