What begins for Chode and crew as a routine mission to protect a pissed-off princess will soon become a filth-splattered saga of dismembered royalty, indestructible clown assassins, and desperately horny housewives. What vile act has Chode committed to bring down the ultimate wrath of Bobo? Can Gus, Six, T'nuk, Whip and Bob stop a time-traveling killing machine from ruining a booze-soaked birthday party? How much does a lap-dance cost at the Grope-a-Cabana on Omicron 9? (The movie consists of footage from the season three episodes "Chode Eraser", "Skankenstein", "Raiders of the Lost Crock of */@?#!", and "Witness Protection" with new bits of additional footage stitching them together into a loosely cohesive whole.)

While the others are being scammed and brainwashed, Whip is out drinking, doing hard drugs, and sowing his wild oats with a bunch of like-minded horny teenagers. Only Gus can pull Whip out of his self-induced state of bliss in order to help him bring the crew safely home. But what's a lecherous lizard to do, have a screw or screw the crew?

When Chode's libido fails to "rise to the occasion," he tries various ways to correct the problem, including doing the nasty with Six in public. Unfortunately, their escapades on the control panel end with the ship accidentally firing lasers at a death star. The expanding star threatens to destroy all in its path. Can the crew save the day or will this really be, "Chode's last stand"?

Chode desperately wants to win The Fifty Million Kronig Flaming Colossus Race. Whip proposes to have Spaceship Bob souped up at his friend Sergio's chop shop. Chode also strikes an endorsement deal with Pucker Up hemorrhoid ointment. Things take a turn for the worse when the upgrade installs a virus into Bob's mainframe.

Dinia, an old flame of Chode's, contacts him and informs him of their son, Chode Jr. Soon, Chode is provided custody and has to take the boy on board, giving him Whip's room. Whip has to sleep in the broom closet.

Commander Adam forces Chode to testify against Darph Bobo in a murder case and puts him in a witness protection program until the trial. Settling down on a suburban planet under the name of "Chance," Chode becomes the object of desire for all the desperate housewives in the neighborhood.

Chode heads down to the Grope-a-Cabana to "catch some snatch" and takes Gus along. There he acquires a medallion that could lead to the treasure of the Pyridians. Meanwhile, the Jupiter 42 and the remaining ship are locked in a tractor beam.

Fortune teller Gypsy Rosaly puts a curse on Chode after he refuses to pay her. Back on the Jupiter 42, Chode has turned invisible and immediately begins to take advantage of the situation. After a while it becomes apparent that the curse is causing Chode to be erased from existence all together.

Six receives an email announcing a hefty inheritance. The crew all wants a piece of the action and come up with a mutinous plan to support Six as their captain instead of Chode.

Darph Bobo's grandfather, Chuckles Schlomo Bobo, has kicked the bucket. One of his last requests is for his arch-nemesis, Benito McBlob to give a eulogy at the funeral. So, it's up to Chode to convince his grandpa to leave the retirement home and say something nice about the man he hated most.

Darph Bobo concocts a convoluted plan to get rid of Chode and Commander Adam at the same time. He kidnaps Six and demands Chode murders Adam within 23.5 minutes. However, Jack Hour of the Alien Terrorist Unit offers to help rescue Six from Intergalactic Airlines flight 69 instead. Once aboard the plane, they find it booby-trapped with deadly snakes.

While visiting an online casino, Gus makes some debts. Soon afterwards, all of the least beat up stuff on the Jupiter 42 starts disappearing...

Chode gets his crew a job as royal bodyguards to the princess of the black and white nation of Slovenia. Despite their presence, the princess falls victim to foul play anyway, so they set about reanimating her in Dr. Skankenstein's long forgotten secret laboratory.

Babbette Bobo is pregnant, apparently by Chode, so her mother Bernice sends the Arnie 1000 android two months back in time to erase Chode before the deed is consummated.