Belinda is a rare female doctor working in a small Missouri town. When her longtime friend, Annie, arrives so that Belinda can watch over her in the last stages of her pregnancy, Annie brings along her mother-in-law, a seen-it-all midwife whose folksy wisdom and remedies are at odds with Belinda's scientific knowledge.

When Clark's beloved wife Ellen dies from scarlet fever, he and his daughter, Missy, must find a way to survive this hardship while saving the barren land from drought.