Roy tries to set John up, with his wife's cousin. An epileptic woman nearly hits a child when he rides out between two parked cars; the ensuing emotional trauma throws her into a mild seizure. A man shoots his son-in-law when he discovers his daughter was married and pregnant without his knowledge. Drug and alcohol addictions rear their heads in four cases: A woman suffering from gangrene in her hand, an alcoholic who collapsed at his home in a hepatic coma, a girl poisoned by taking pills laced with sodium hydroxide (who subsequently dies), and a man suffering from tetanus. Other rescues include an obese man whose pacemaker has failed and freeing an asthmatic child whose has gotten an arm stuck in a swimming pool drain, with the help of Dixie, Dr. Early, John and Roy, while in the hospital.

When Roy and his wife, Joanne, have a fight, John helps them out, which makes the situation worse. During the rescue of a man whose car is hanging over a bridge, the erratic instructions and behavior of a new doctor, Dr. Varner concern Dixie. Dr. Varner later catches an atrial myxoma, that Drs. Early and Brackett had both missed, but she then is found asleep in her car, and Dixie learns the reason for her behavior. The firefighters assist a man who had fallen off a roof trying to get his dog down (then they rescue the dog), and two children lost in a rapidly flooding storm drain.