The Tick falls prey to an uncommon cold and is a less then subtle sufferer - Arthur while tending him goes next door and is kidnapped by Thrakkorzog, evil ruler of Dimension 14B. Thrak plans to conquer Earth with an army of Tick clones, but all that an Arthur-clone can get in the way of Tick's cell samples is mucus from his handkerchiefs. This leads to the creation of Mucus Tick, whom The Tick must battle for the sake of the world!

The government asks the Tick and Arthur to help when a space capsule with a monkey (with super smarts due to exposure with cosmic rays) crash lands in Pokoponesia - the heroes must recover the monkey. The two plus American Maid go there and find themselves in battle with the country's evil ruler, Pineapple Pokopo.