The Terror meets The Tick for the first time, and tries to take over The City.

As The Tick and Arthur return to The City from a trip, The City is too quiet. Soon, they learn that a clown is terrorizing the city. Unfortunately, The Tick is knocked into his own mind, for a journey of discovery.

The Mole Men come to the surface on vacation and the Tick ends up being their tour guide and protector - they meet supermodel Mindy Moleford and pursue her romantically. Complicating matters is the arrival of the Lava Man, who tries to kill the Mole King.

The government asks the Tick and Arthur to help when a space capsule with a monkey (with super smarts due to exposure with cosmic rays) crash lands in Pokoponesia - the heroes must recover the monkey. The two plus American Maid go there and find themselves in battle with the country's evil ruler, Pineapple Pokopo.

While shopping, the Tick and Arthur run afoul of Charles, aka Brainchild - a 9-year old with his brain in a transparent dome on his head. Assisted by his cyborg dog Skippy, Charles uses his multi-mega-destructor cannon to smash the Moon into the Earth, and only the Tick can save the day!

The Tick falls prey to an uncommon cold and is a less then subtle sufferer - Arthur while tending him goes next door and is kidnapped by Thrakkorzog, evil ruler of Dimension 14B. Thrak plans to conquer Earth with an army of Tick clones, but all that an Arthur-clone can get in the way of Tick's cell samples is mucus from his handkerchiefs. This leads to the creation of Mucus Tick, whom The Tick must battle for the sake of the world!

The Tick, Arthur, Die Fliedermaus, and Sewer Urchin visit The Comet Club in Dot's car. Arthur is denied entry by "The Doorman", as he is a sidekick. The heroes are shocked to learn of The Tick, as they know a different The Tick, Barry. As those two fight, The Evil Midnight Bomber what Bombs at Midnight is seeding The Comet Club with bombs, which no superhero seems to notice...

El Seed has mobilized the plants to help him take over the world. Arthur and The Tick infiltrate his army; when asked what kind of corn soldiers they are, Arthur says they are "kernels/colonels".

The Breadmaster and his sidekick, Buttery Pat, plot to conquer The City by baking a giant Lemon Dessert Souffle and only The Tick and Arthur can stop him. The Tick uses the Human Cannon's cannon to fire himself, create a sonic boom, and collapse the Souffle before it can crush The City.

Mr. Mental invites the Tick and Arthur to his stage show at the Evil Eye so that he can hypnotize the Tick to steal a device that will allow him to take over the world.

Dinosaur Neil talks about dinosaurs at his job, but when he is eating his lunch in the lab (even though a sign clearly states "Don't Eat in the Lab"), he accidentally ingests Dinosaur DNA, becomes a dinosaur, and rampages through the city.

The Tick and Arthur are on patrol, and spot some suspicious activity. The get involved, blowing American Maid's plan to follow the thugs. Luckily they find an invitation to Chairface Chippendale's birthday party. Unlike other criminals, Chairface doesn't want to make his mark on the world...

The Tick arrives in 'The City' and shortly after meeting Arthur, his side-kick to be, is called into action to foil the evil plans of the 'Idea Men'. Tick and Arthur manage to thwart the Idea Men's plan to blow up the City Dam.