El Dentista follows Nolasco Black, a forensic dentist investigating the brutal murder of a prostitute. As he digs deeper into the case, he relives a personal tragedy and uncovers evidence that Jack the Ripper has arrived in America. With the support of the secret society Flammarion and Sofía, a brilliant chemist who becomes both his ally and love interest, Nolasco embarks on a dangerous hunt to stop the killer before more victims fall.