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As the Thanksgiving holiday approaches, the Children of Liberty prepare a new initiative to wipe out the aliens among them. James and Lena have their first major argument, and Nia displays narcolepsy but refuses help.
When Jensen--the new Parasite--attacks aliens, Supergirl is forced to take to the sidelines rather than give him further power. As a result, Kara writes an article on an alien healer who makes him a target. Meanwhile, Alex learns some surprising things about her new superior, and James comes to a realization about the Children of Liberty and their anti-alien agenda.
Hank assures Supergirl that Manchester is a trustworthy ally. Meanwhile, James meets with Agent Liberty and has to choose between betraying his reputation or committing an act of terrorism for the Children of Liberty.